Historical review of interstitial prostate brachytherapy
نویسندگان
چکیده
In the recent years, interstitial brachytherapy implantation has become the treatment of choice for early stage prostate cancer patients (1, 2, 3). Popularity of this modality is most likely due to the fact that five-and ten-year disease control rates of brachytherapy are equal to those of the surgical and external radiation therapy, whereas, the toxicity and side-effects are perceived to be lower (4,5). It has been estimated that up to 50% of patients with early stage prostate cancer are now treated with ultrasound-guided transperineal interstitial brachytherapy (3-7) with I-125 or Pd-103 radioactive seeds. The principal advantage of this technique is that the seeds can deliver a substantially higher radiation dose to the prostate and less radiation dose to the surrounding tissue compared with external beam irradiation (8, 9). Iodine-125, Pladium-103, and most recently introduced Cs-131 are the most suitable radiation sources for this treatment modality. These sources emit low energy photons and the dose falls quickly with the distance and therefore, seeds deliver low dose to the adjacent rectum and bladder (10-14).
منابع مشابه
Historical review of interstitial prostate brachytherapy
In the recent years, interstitial brachytherapy implantation has become the treatment of choice for early stage prostate cancer patients. Treatment of prostate cancer with radiation is traced back to 1909. Originally this treatment modality was very crude and could not gain much popularity till 1982. Advancements in radioactive source designs, introduction of new low energy radioactive sources,...
متن کاملModern brachytherapy for treatment of prostate cancer.
BACKGROUND Prostate cancer is the most common cancer diagnosed in men. An increasing number of these patients are seeking minimally invasive procedures such as transperineal interstitial permanent radioactive seed prostate brachytherapy. METHODS This paper reviews the historical perspective and the current advances in transperineal interstitial permanent radioactive seed prostate brachytherap...
متن کاملA cold spot compensation technique using a combination of trans-rectal ultrasonography and intraoperative computed tomography for interstitial permanent prostate brachytherapy: a single-arm prospective trial
Purpose To evaluate the efficacy of a cold spot compensation technique using a combination of trans-rectal ultrasonography (TRUS) and computed tomography (CT) for permanent interstitial prostate brachytherapy. Material and methods Sixty-five patients were treated with the cold spot compensation technique using TRUS-CT fusion. The prescribed dose was set at 145 Gy. The dose to 90% of prostate ...
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High-risk prostate cancer represents a therapeutic challenge for both the urologist and radiation oncologist. Biochemical outcomes with radical prostatectomy and external-beam radiation therapy are poor in this subset of patients. These unfavorable results have led some to believe that high-risk prostate cancer is not curable with conventional treatment approaches, which has been an impetus for...
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